Ph.D. Studentship National Biophotonics and Imaging Platform Ireland (NBIPI)

May 21, 2008

A Ph.D. Studentship is available in the Department of Physiology funded through the National Biophotonics and Imaging Platform Ireland (NBIPI).

We are interested in hearing from highly-motivated and enthusiastic science graduates who wish to pursue a Ph.D., and a career, in biomedical sciences, apoptosis research and molecular imaging. The successful candidate will get to work in highly stimulating, Science Foundation Ireland- and EU-funded laboratory interested in identifying cell death and cell survival pathways in cancer cells and neurons.

The postgraduate students will be enrolled in a structured Ph.D. program at the RCSI, and will receive additional training in biophotonics and imaging via the NBIPI training program [please find more details on the NBIPI Educational Programme at http://www.nbipireland.ie/]

Project: The project will analyse the activation and interaction kinetics of cell death-inducing and cell death-antagonising Bcl-2 family proteins during stress-induced apoptosis. Tedhniques employed will include state-of-the-art confocal GFP imaging and FRET analysis, high content analysis platforms, and molecular biology approaches. The day-to-day supervision is supported by the Director of Molecular Imaging and the Laboratory manager.

References:
Ward MW, Rehm M, Duessmann D, Kacmar S, Concannon CG, Prehn JHM. Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis. J Biol Chem 2006: 281, 5837-44.

Rehm M, Huber HJ, Duessmann H, Prehn JHM. Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein. EMBO J 2006 25: 4338-49.

Interested candidates are invited to send a C.V., a brief cover letter indicating their specific interests, and a list of up to three references by email to Prof Jochen Prehn (prehn@rcsi.ie).

Tags: Biophotonics, Imaging, Ireland, NATIONAL, NBIPI, PhD, Platform, Studentship

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