Canada Graduate student position in molecular evolution of genetic information

April 7, 2008

Graduate student position in molecular evolution of genetic information
systems

Genetic information is stored in the cell in the form of DNA, which the
cell cannot access directly. Instead, DNA information undergoes
extensive, multistep processing before it can be acted upon to direct
cellular functions. One of these processes, alternative mRNA splicing,
not only transmits genetic information but also enhances it by
generating multiple alternative genetic messages from the same gene. The
cell expands considerable amount of resources to generate these
alternative messages and while some are essential for the proper
functioning and development of the cell, the significance of others is
subject of great debate since their function in the cell is unclear.
Are they errors tolerated by the cell or do they represent an as yet
unknown type of genetic information or a novel regulatory process?

Graduate student positions are available, either MSc or PhD, to evaluate
the significance of alternative messages by comparing their production
in a variety of animals including primates, other mammals, birds, fish,
and amphibians. Our guiding principle is that if alternative messages
are functionally important then we will be able to trace their
evolutionary development and uncover evidence of their role in the
various animals we will investigate.

Student financial support is available for Canadian citizens and landed
immigrants.

For additional information, please contact:

Dr. Adonis Skandalis
Dept. Biological Sciences
Brock University
St. Catharines, Ont. L2S 3A1
adonis.skandalis@brocku.ca

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