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Postdoctoral position on Stem cell Aging/Cancer Stem Cells (Ulm, Germany)
January 24, 2008
2 postdoctoral positions at the Max-Planck-Research-Group and the Institute of Molecular Medicine at the University of Ulm.
The applicant should have a strong background in research on stem cells and/or mouse models. Experience with mouse ES cell culture and Microinjection. Two projects are started:
(i) Molecular mechanisms limiting adult stem cell function during aging and in response to DNA damage or telomere shortening.
(ii) Molecular mechanisms inducing stem cell derived cancer in response to aging and telomere dysfunction.
Related papers:
Choudhury RA, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee HW, von Zglinicki T, Ganser A, Schirmacher P, Nakauchi H, Rudolph KL. p21-deletion prolongs lifespan of telomere dysfunctional mice without accelerating cancer formation. Nat Genet. 2007; 39:99-105.
Ju Z, Jiang H, Jaworski M, Rathinam C, Gompf A, Klein C, Trumpp A, Rudolph KL. Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat Med. 2007; 13:742-7.
Schaetzlein S, Kodandaramireddy NR, Ju Z, Lechel A, Stepzynska A,Lilli DR, Clark AB, Rudolph C, Kuhnel F, Wei K Schlegelberger B, Schirmacher P, Kunkel TA, Greenberg RA, Edelmann W, Rudolph KL. Exo1 de-letion impairs DNA damage signalling and prolongs lifespan of telomere dysfunctional mice. Cell 2007, 130:863-77.
Tags: Aging, Cancer Stem Cells, Germany, Postdoctoral Position, Stem cell, Ulm
Posted by Open Scholarships | Scholarship Category Germany Scholarships, Postdoctoral Scholarships
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