Bioinformatics PhD available on bacterial “ORFans”-UK

January 24, 2008

Bioinformatics PhD available on bacterial “ORFans”

This is a collaborative project supervised jointly by Dr Edward Feil
(University of Bath, UK), and Dr Dawn Field (University of Oxford, UK).

Our collection of genomes and metagenomes continues to grow at an
increasing pace. These data provide great potential for understanding
both evolutionary and ecological processes, but new software tools and
statistical approaches are required to manage and to fully exploit the
datasets. Each newly sequenced genome reveals a number of previously
unkown genes ( ?ORFans?). These genes are likely to be of central
importance to bacterial adaptation, yet they remain largely
understudied. You will join the microbial adaptation group led by Dr Ed
Feil at the University of Bath, and the evolutionary bioinformatics
group at CEH Oxford led by Dawn Field, to further develop comparative
genomic software to understand the evolutionary significance of newly
identified hypothetical gene sequences. It is invisaged that most of
your time will be spent in Oxford.
You will use your programming and database skills to extend the current
infrastructure, including the provision of a public web server from
cached and uploaded data sets.In addition to gaining extensive
bioinformatics expertise, the project will also involve a strong
appreciation of bacterial population biology and micro-evolution. In
undertaking these studies you will work with a range of existing
collaborators in the USA and Europe and build new suitable
collaborations in the course of your PhD research.

This project has funding associatated with it. It is a 4-year
studentship. Eligible candidates are UK or EU applicants, who have been
resident in the UK for at least the 3 years prior to the start of the
research programme.

It is envisaged that this studentship will start in early 2008.

Applicants can download an application form, together with advice on
the application procedure, from the University of Bath website at
http://www.bath.ac.uk/grad-office/apply/index.html.
Alternatively, please contact the Postgraduate Administrator, Dr Emma
Lawrence for further information and advice on the project and the
application procedure.

Alternatively please contact Ed Feil directly at e.feil@bath.ac.uk.

Recent Publications:

G.A. Wilson, E.J. Feil, A. Lilley & D. Field 2007 The large-scale
comparative genomic ranking of lineage-specific predicted proteins in
bacterial and archaeal genomes. PLoS ONE. 2(3):e324
Wilson, G.A. , Feil, E.J. Field, D. 2005.Databases and Software for the
comparison of prokaryotic genomes. Microbiology. 151:2125-32.
Wilson, G.A., Bertrand, N. Patel, Y., Hughes, JB, Feil, E.J., Field, D.
2005 Orphans as taxonomically restricted and ecologically important
genes. Microbiology. 2005 151:2499-501

e.feil@bath.ac.uk

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